Package: Certara.NLME8
Version: 3.2.0
Title: Utilities for Certara's Nonlinear Mixed-Effects Modeling Engine
Authors@R: c(
      person("Soltanshahi", "Fred", email = "fred.soltanshahi@certara.com", role = c("aut")),
      person("Michael", "Tomashevskiy", email = "michael.tomashevskiy@certara.com", role = c("aut")),
      person("James", "Craig", email = "james.craig@certara.com", role = c("aut", "cre")),
      person("Shuhua", "Hu", role = c("ctb")),
      person("Certara USA, Inc.", role = c("cph","fnd"))
      )
Description: Interface to Certara's Nonlinear Mixed-Effects (NLME) modeling
    engine ('NLME-Engine') for pharmacokinetic and pharmacodynamic (PK/PD)
    modeling and simulation. Provides access to the Maximum Likelihood
    estimation algorithms available in the 'Phoenix' NLME platform for
    population, individual, and pooled analyses using parametric methods.
    Includes utilities for setting up NLME installations and
    parallel settings, running estimation, bootstrap, and covariate search
    workflows, and updating model files from engine output. Jobs can be
    executed locally or across high-performance computing resources,
    including Linux Sun Grid Engine (SGE) and Simple Linux Utility for
    Resource Management (SLURM) grids as well as multicore Linux and
    Windows hosts.
Depends: R (>= 4.0.0)
License: LGPL-3
Suggests: testthat, brew, withr
Imports: xml2, batchtools (>= 0.9.9), utils, data.table
Encoding: UTF-8
Config/roxygen2/version: 8.1.0
NeedsCompilation: no
Packaged: 2026-09-11 17:12:54 UTC; jcraig
Author: Soltanshahi Fred [aut],
  Michael Tomashevskiy [aut],
  James Craig [aut, cre],
  Shuhua Hu [ctb],
  Certara USA, Inc. [cph, fnd]
Maintainer: James Craig <james.craig@certara.com>
Repository: CRAN
Date/Publication: 2026-09-11 20:20:02 UTC
Built: R 4.5.3; ; 2026-09-11 23:52:18 UTC; windows
