Package: glmmSeq
Title: General Linear Mixed Models for Gene-Level Differential
        Expression
Version: 0.5.7
Authors@R: 
    c(person(given = "Myles",family = "Lewis",
    role = c("aut", "cre"),
    email = "myles.lewis@qmul.ac.uk",
    comment = c(ORCID = "0000-0001-9365-5345")),
    person(given = "Katriona",family = "Goldmann",
    role = c("aut"),
    email = "k.goldmann@qmul.ac.uk",
    comment = c(ORCID = "0000-0002-9073-6323")),
    person(given = "Elisabetta",family = "Sciacca",
    role = c("aut"),
    email = "e.sciacca@qmul.ac.uk",
    comment = c(ORCID = "0000-0001-7525-1558")),
    person(given = "Cankut",family = "Cubuk",
    role = c("ctb"),
    email = "c.cubuk@qmul.ac.uk",
    comment = c(ORCID = "0000-0003-4646-0849")),
    person(given = "Anna", family = "Surace",
    role = c("ctb"),
    email = "a.surace@qmul.ac.uk",
    comment = c(ORCID = "0000-0001-9589-3005")))
Description: Using mixed effects models to analyse longitudinal gene expression can highlight differences between sample groups over time. The most widely used differential gene expression tools are unable to fit linear mixed effect models, and are less optimal for analysing longitudinal data. This package provides negative binomial and Gaussian mixed effects models to fit gene expression and other biological data across repeated samples. This is particularly useful for investigating changes in RNA-Sequencing gene expression between groups of individuals over time, as described in: Rivellese, F., Surace, A. E., Goldmann, K., Sciacca, E., Cubuk, C., Giorli, G., ... Lewis, M. J., & Pitzalis, C. (2022) Nature medicine <doi:10.1038/s41591-022-01789-0>.
License: MIT + file LICENSE
Encoding: UTF-8
LazyData: true
biocViews:
RoxygenNote: 7.3.2
Language: en-gb
URL: https://myles-lewis.github.io/glmmSeq/,
        https://github.com/myles-lewis/glmmSeq
BugReports: https://github.com/myles-lewis/glmmSeq/issues
Suggests: knitr, rmarkdown, DESeq2, edgeR
VignetteBuilder: knitr
Depends: R (>= 3.6.0)
Imports: car, emmeans, stats, ggplot2, ggpubr, glmmTMB, graphics, MASS,
        lme4, lmerTest, kableExtra, mcprogress, methods, plotly,
        qvalue, pbapply
NeedsCompilation: no
Packaged: 2025-10-01 19:04:10 UTC; elisabetta
Author: Myles Lewis [aut, cre] (ORCID: <https://orcid.org/0000-0001-9365-5345>),
  Katriona Goldmann [aut] (ORCID:
    <https://orcid.org/0000-0002-9073-6323>),
  Elisabetta Sciacca [aut] (ORCID:
    <https://orcid.org/0000-0001-7525-1558>),
  Cankut Cubuk [ctb] (ORCID: <https://orcid.org/0000-0003-4646-0849>),
  Anna Surace [ctb] (ORCID: <https://orcid.org/0000-0001-9589-3005>)
Maintainer: Myles Lewis <myles.lewis@qmul.ac.uk>
Repository: CRAN
Date/Publication: 2025-10-02 05:10:14 UTC
Built: R 4.6.0; ; 2026-04-15 04:58:49 UTC; windows
