IMPORTANT! Dowser’s source code has moved to https://github.com/immcantation/dowser

To update Git configuration settings use:

   git config user.email "your-gh-user@email.com"
   git config user.name "your-gh-user-name"
   git remote set-url origin git@github.com:immcantation/dowser.git

Dowser

Dowser is part of the Immcantation analysis framework for Adaptive Immune Receptor Repertoire sequencing (AIRR-seq). Dowser provides a set of tools for performing phylogenetic analysis on B cell receptor repertoires. It supports building and visualizing trees using multiple methods, and implements statistical tests for discrete trait analysis of B cell migration, differentiation, and isotype switching.

Dowser has 6 primary functions:

1. Reconstruct clonal germline sequences.
2. Build B cell lineage trees using multiple methods, such as maximum parsimony, maximum likelihood, and IgPhyML.
   
3. Reconstruct intermediate sequences within lineage trees using different methods.
4. Create publication-quality lineage tree plots.
5. Analyze trees to detect ongoing B cell evolution over time.
6. Understand B cell migration and differentiation.

What’s a dowser?

Documentation and tutorials

Full documentation, including tutorials and vignettes: https://dowser.readthedocs.io

Contact

If you need help or have any questions, please contact the Immcantation Group.

If you have discovered a bug or have a feature request, you can open an issue using the issue tracker.

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