AdaptiveTrialsR: Bayesian and Adaptive Clinical Trial Simulation and Monitoring
Provides tools for simulating, monitoring, and evaluating
Bayesian and adaptive clinical trial designs with binary outcomes.
The package includes methods for trial simulation, posterior and
predictive probability monitoring, adaptive randomization,
Bayesian treatment-effect estimation, dose-finding designs,
two-stage phase II trial designs, group sequential monitoring,
operating-characteristic evaluation, interim analyses, and
decision-support procedures. The methodological foundation includes
the two-stage phase II design described by Simon (1989)
<doi:10.1016/0197-2456(89)90015-9>.
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